MCL1 and colonic neoplasm: Combined inhibition of both Mcl-1 and Bcl-xL caused nearly complete cell death after 24 hr in all colon cancers except HCT-116; further analyses showed that αMCL1-mediated Mcl-1 inhibition strongly sensitizes most colon cancers to A-1331852 (and to a lesser extent ABT-263), with a 4.6-fold or greater decrease in EC50 values observed in all cell lines except HCT-116 (Figure 9—figure supplement 1A–B).