We also provide further evidence that many colon cancers are dependent on Mcl-1 and Bcl-xL for survival; mRNA profiling indicates Mcl-1 and Bcl-xL are indeed more prevalent than other BCL2 homologs in many colon cancers, but resistant HCT-116 is indistinguishable from sensitive lines like Caco-2 and HT-29 (Placzek et al., 2010). Here, BCL2 is linked to malignant colon neoplasm.