Earlier researchers found that many factors may influence the process of LV remodelling, such as patency of the infarctrelated artery,23 treatment with angiotensin converting enzyme (ACE) inhibitors and/or beta-blockers,24 and baseline BNP concentrations.25 Treatment with renin–angiotensin–aldosterone blockers after MI was found to ameliorate the process of LV remodelling in experimental models26 as well as in humans.3,27. This evidence concerns the gene NPPB and myocardial infarction.