Because of the strong effect of APOE e4 on LOAD risk observed in this study [e3/e4 vs. e3/e3: adjusted odds ratio (AOR) = 3.5; e4/e4 vs. e3/e3: AOR = 17.7] and a previous meta-analysis of Japanese subjects [e3/e4 vs. e3/e3: odds ratios (OR) = 3.9; e4/e4 vs. e3/e3: OR = 21.8]7, APOE e4 status was forced into the genetic model for AD. The gene discussed is APOE; the disease is Alzheimer disease.