Of special note, although the current sample size may be still underpowered, variants locating GTF2I-GTF2IRD1showed the genome-wide associations with p < 5 × 10−8 and with high altitude of effect size (OR > 2), highlighting important etiology role of GTF2I-GTF2IRD1 in SLE. The gene discussed is GTF2I; the disease is systemic lupus erythematosus.