In addition, it had been reported that rs8032939 associated with rheumatoid arthritis and rs8035957 associated with type 1 diabetes in several GWASs (the NHGRI-EBI GWAS Catalog, http://www.ebi.ac.uk/gwas), suggesting RASGRP1 variants were pleiotropic and likely causal variants affecting multiple autoimmune diseases susceptibility. This evidence concerns the gene RASGRP1 and type 1 diabetes mellitus.