HIF1A and neoplasm: Whereas overexpression of HIF-1 was associated with therapeutic resistance in 5-aminolevulinic acid (5-ALA)-PDT-treated human esophageal carcinoma cells [56], combination therapy of siRNA-mediated knockdown of HIF-1 with Photosan-PDT significantly improved therapeutic efficacy in human head-and-neck cancer (SCC4, SAS) tumor-bearing mice [57].