FGF21 and myocardial infarction: The beneficial effects of Ad-FGF21 on cardiac dysfunction and inflammatory responses after myocardial infarction are diminished in adiponectin-knockout mice, indicating that muscle-derived FGF21 ameliorates adverse cardiac remodeling after myocardial infarction, at least in part, through an adiponectin-dependent mechanism (Joki et al., 2015).