The discovery in 2003 that Hutchinson-Gilford progeria syndrome (HGPS), a rare premature aging disease that affects children, is caused by ade novo LMNA mutation that leads to impaired processing of prelamin A and the production of a permanently farnesylated mutant lamin A protein termed progerin11,12 has led to an escalation in lamin research with the hope of finding a cure for this devastating disease. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.