ADAM17 and endothelial dysfunction: In addition, it was observed that unsaturated fatty acids in LDL particles are also involved in ADAM17 activation in the endothelial layer, due to increase in membrane fluidity, creating a link between endothelial dysfunction/atherosclerosis and increase in ADAM17 substrates in patients at risk (Reiss et al., 2011; Menghini et al., 2013).