Moreover, ADAM17 can control the transcription of matrix metalloproteinase-2 (MMP-2), which in turn mediated angiotensin-II (Ang-II)-induced hypertension in mice independently of cardiac hypertrophy or fibrosis, showing that the effects of ADAM17 in the cardiovascular system may be connected to other metalloproteinases (Odenbach et al., 2011). This evidence concerns the gene AGT and cardiac hypertrophy.