CASR and colorectal neoplasm: CaSR expression is lost in colorectal tumors (Sheinin et al., 2000; Chakrabarty et al., 2005; Fetahu et al., 2014a), mainly due to epigenetic silencing i.e., DNA hypermethylation, histone deacetylation, increased expression of the mircroRNAs miR-135b, miR-146b (Hizaki et al., 2011; Fetahu et al., 2014a, 2016).