MAOB and Parkinson disease: Safinamide, an orally active alpha-aminoamide derivative, is a novel reversible and highly selective MAO-B inhibitor which is efficacious as add-on therapy to DA agonists in early-stage PD (Stocchi et al., 2004, 2012) and as adjunct to LD in mid- to late-stage PD (Borgohain et al., 2014).