TP53 and Alzheimer disease: Regardless of the specific protein/mechanism compromised, we believe that HSV-1-induced accumulation of DSBs in neuronal genome might induce neurodegeneration through different pathways (i.e., p53-mediated apoptosis, autophagy deficiency and cell cycle re-entry), as observed in AD (Roos and Kaina, 2006; Ghavami et al., 2014; Chow and Herrup, 2015).