PRKDC and Alzheimer disease: Herpes simplex virus-1 (HSV-1), a neurotropic virus suggested to play a co-factorial role in AD (reviewed in De Chiara et al., 2012), was reported to inhibit NHEJ in epithelial cells, targeting DNA-PK for proteasomal degradation (Lees-Miller et al., 1996; Parkinson et al., 1999).