RELN and Alzheimer disease: In humans, genetic studies have reported that the RELN locus is associated with neuropsychiatric disorders, such as Schizophrenia (SZ), bipolar disorder (BP), autism spectrum disorder (ASD) and Alzheimer’s disease (AD; Ovadia and Shifman, 2011; Wang et al., 2014; Bufill et al., 2015; Li et al., 2015).