A number of studies have revealed that Reelin also plays a pivotal role in regulating synaptic functions, including N-methyl-d-aspartate (NMDA) receptor signaling (Beffert et al., 2005; Qiu et al., 2006b), and these findings may give a clue to uncover the impairments in the Reelin signaling pathway underlying the development of psychiatric disorders. Here, RELN is linked to psychiatric disorder.