We and other groups have likewise reported that anti-Nogo-A treatment enhances recovery from hemispatial neglect after aspiration lesion of the medial agranular cortex (Brenneman et al., 2008) and recovery of cognitive function after traumatic brain injury (Lenzlinger et al., 2005; Marklund et al., 2007), positioning Nogo-A as a promising therapeutic target for improving cognition after brain injury. This evidence concerns the gene RTN4 and brain injury.