Nogo-A signaling has also been shown to inhibit nerve growth factor-mediated CREB phosphorylation in vitro (Joset et al., 2010), whereas CREB phosphorylation is important for the maturation and survival of newborn dentate granule cells, including after stroke (Zhu et al., 2004; Jagasia et al., 2009). The gene discussed is RTN4; the disease is Stroke.