For example, the apoptosis signal-regulating kinase 1 (ASK1), a MAP kinase-kinase-kinase implicated in apoptosis, inflammation, proliferation and migration, activates c-Jun N-terminal kinase (JNK) and p38 and is clearly related to tumorigenesis in liver, skin, melanoma and colon cancers [4]. Here, MAP3K5 is linked to malignant colon neoplasm.