The care for patients with childhood-onset GH deficiency (CO-GHD), those born small for gestational age (SGA), girls with Turner syndrome (TS), patients with Prader–Willi syndrome (PWS), and survivors of cancers treated during childhood was addressed and, specifically, the role for GH therapy in patients with CO-GHD. The gene discussed is GH1; the disease is Prader-Willi syndrome.