The cytokine milieu of AD skin lesions show Th2-dominant responses indicated by the excessive production of thymus- and activation-regulated chemokine (TARC) and interleukin (IL)-4, IL-5, and IL-13 that leads to an immune response resulting in elevated serum immunoglobulin E (IgE) levels (5). This evidence concerns the gene CCL17 and Alzheimer disease.