In general, severe enteropathy develops in humans deficient in Foxp3 expression and mice deficient in Tregs (33–35), and Foxp3+ Tregs of psoriasis patients are susceptible to differentiation into IL-17A that has a highly pathogenic role in skin inflammation and the development of psoriatic plaques (36–38). Here, FOXP3 is linked to Abnormal intestine morphology.