PKLR and type 2 diabetes mellitus: For the up-regulated DEGs, KEGG pathway analyses indicated that they were significantly enriched in four pathways such as arachidonic acid metabolism (e.g., CYP2J2, CYP2B6, and GPX3), metabolism of xenobiotics by cytochrome P450 (MOXBCP) (e.g., UGT1A7, UGT1A10, and UGT1A6), maturity onset diabetes of the young (e.g., HNF1A, SLC2A2, and PKLR) and Drug metabolism (DGM) pathways (e.g., UGT1A7, UGT1A10, and UGT1A6) (Table 2).