Brain derived neurotrophic factor delivered by cannula or osmotic pump to the vestibular nucleus complex has been shown to be effective in damping nystagmus following an experimental labyrinthectomy.37 While nystagmus induced by a labyrinthectomy is different from idiopathic forms that occur in childhood in the absence of brain or other known injury, the efficacy of BDNF in this context is very interesting. This evidence concerns the gene BDNF and pathologic nystagmus.