While IL10 can be produced by various cell populations, including B cells, monocytes, NK cells, Th2-type T cells, and Type 1 Tregs (Tr1 cells), several studies suggest that IFNγ+IL10+ Th1 cells are a particularly important source of IL10 in human and murine parasitic infections [9, 50, 53]. The gene discussed is IFNG; the disease is parasitic infectious disease.