The unique feature of nuclear actin polymerization induced by AcMNPV requires the accumulation of the cytoplasmic actin polymerization machinery, including Arp2/3, in the nucleus [27, 29–31], which makes this virus-infection system ideally suited as a research model for investigating the nucleo-cytoplasmic shuttling mechanism of Arp2/3. Here, ACTR2 is linked to infection.