We then performed similar tests in osteoclast precursors using the SERM bazedoxifene and found that neither multi-nuclear TRAP-positive osteoclast formation nor osteoclastic gene expression was suppressed (Fig 3A–3C), although bazedoxifene has been shown to inhibit osteoclast bone resorption in post-menopausal osteoporosis patients [29, 30]. This evidence concerns the gene ACP5 and osteoporosis.