MMP2 and Ascending tubular aorta aneurysm: This study is limited by its rather small patient groups, subgroups of patients with ascending aortic aneurysms, especially patients with bicuspid and tricuspid aortic valves should be investigated in a larger study to evaluate the potential of MMP-2 isoforms as indicators of high wall stress or to definitely rule out the suitability of MMP-2 as such a marker.