Neurospheres derived from hiPSCs from subjects with schizophrenia showed abnormal phenotypes similar to neurospheres derived from Dgcr8 heterozygous knockout mice.10 Therefore, we focused on the changes in microRNA (miRNA) expression potentially elicited by DGCR8 haploinsufficiency, and investigated subsequent molecular cascades. Here, DGCR8 is linked to schizophrenia.