Altering the expression of Crmp2 in cultured rat hippocampal neurons significantly affects axonal growth.15, 16 Further, multiple proteomic studies report aberrant expression of CRMP2 in the brains of schizophrenics.17, 18, 19, 20 Most recently, a study showed downregulation of the Crmp2 protein in the prefrontal cortex and hippocampus of prenatally stressed rats.21 The study also reported two single-nucleotide polymorphisms associated with schizophrenia (SZ) susceptibility, further suggesting a role for DPYSL2 in this disease.21 This evidence concerns the gene DPYSL2 and schizophrenia.