Specifically, Gas6 and TAM seem to play a protective role against inflammatory demyelination, likely as the result of multiple mechanisms: a neurotrophic effect [24], an anti-inflammatory effect on microglia, and [86] a trophic effect on oligodendrocytes mediated by Axl [83,84], and a pro-phagocytic action, mediated by both Axl and MerTK [61]. Here, GAS6 is linked to Peripheral demyelination.