To date, the melanoma initiation and progression have been associated with signaling pathways, including PTEN (Phosphatase And Tensin Homolog)/AKT (V-Akt Murine Thymoma Viral Oncogene Homolog), WNT (Wingless-Type MMTV Integration Site Family)/β-catenin, and Ras/Raf/MEK (MAP kinse-ERK kinase)/ERK (extracellular regulated MAP kinase), and microRNAs (miRNAs) have been implicated as key regulators of these signaling pathways in recent studies [3,4]. This evidence concerns the gene PTEN and melanoma.