SUFU and neoplasm: SOX7 is a negative regulator ofthe WNT/β-catenin signaling pathway (Chan etal., 2012) and can also be a tumor suppressor (Takash et al., 2001).SUFU is related to the biological process of organ development andis included in the Hedgehog signaling pathway, of which it is a negative regulator bysuppressing the activity and function of GLI transcription factors (Ding et al., 1999).