While these studies relied on strong-antigen driven tumor models, it is likely that loss of DGKs also enhances T cell anti-tumor activity in tumors with low-grade antigens, since DAG-mediated activation of RasGRP1 regulates the threshold for T cell activation (Das et al., 2009), and earlier studies implicated a role for Ras in Jurkat T cell activation mediated by low grade TCR stimulus (Perez de Castro et al., 2004). The gene discussed is RASGRP1; the disease is neoplasm.