DGKZ and Autoimmunity: Although mice deficient in DGKα, DGKζ, or both do not develop overt autoimmunity, it is likely that the mice would develop enhanced T cell responses in autoimmune models such as experimental autoimmune encephalitis (EAE), especially given the role DGKs play in limiting activation of Mnk1/2-mediated activation and development of encephalitis in the EAE model (Gorentla et al., 2013).