DGKA and renal cell carcinoma: DGKα has also been evaluated as a potential target to improve T cell activity against tumor, based on the observation that DGKα is upregulated in certain inhibited T cell conditions, such as anergy (Zha et al., 2006), and that DGKα is upregulated in tumor-infiltrating lymphocytes in human renal cell carcinoma (Prinz et al., 2012).