This suggests that one can predict, in broad terms, how DGK-deficient T cells will respond to various immunosuppressive pathways within the tumor microenvironment, in that one would anticipate DGK-deficient T cells to be insensitive to inhibitors that directly attenuate TCR signaling, such as PD-1 or Lag3, but sensitive to inhibitory pathways that do not directly interfere with TCR signaling, such as Tim3 or CTLA-4. Here, DGKE is linked to neoplasm.