Although the study suggested Notch-mediated IL-22 protected RBP-J−/− mice from ConA-induced hepatitis (Alam et al., 2010), more recent study on experimental autoimmune uveoretinitis revealed a key pathological role of RBP-J/Notch-induced IL-22 production in late phase of the disease (Bhuyan et al., 2014). Here, RBPJ is linked to hepatitis A virus infection.