Systemic and intravitreal corticosteroids, hyperbaric oxygen therapy, anticoagulant therapy, and intravitreal anti-VEGF therapy have been used in treatment.139,140,141,142 Finger and Chin139 treated 14 choroidal melanoma patients who developed radiation-induced optic neuropathy after radioactive plaque therapy with intravitreal anti-VEGF injections (at least 2 injections at 6-8 week intervals) and reported regression of optic disc edema and improvement of papillary hemorrhage. This evidence concerns the gene VEGFA and optic papillitis.