Etanercept, another anti-TNF agent, has been determined effective in the treatment of other rheumatologic manifestations of JIA but has not shown sufficient efficacy in JIA-associated uveitis and is even reported to lead to relapses causing the emergence of uveitis.50,51,52,53 Our knowledge concerning the efficacy of golimumab and certolizumab pegol, also in this group of biologics, is limited to case studies; randomized clinical studies investigating the efficacy of these agents have yet to be conducted.54,55. This evidence concerns the gene TNF and juvenile idiopathic arthritis.