It has been considered a subgroup of age-related macular degeneration (AMD), but the presence of polypoidal lesions beyond the macula and differing responses to treatment suggest it is a separate pathology.1 Polypoidal lesions may be visible as red-orange lesions on fundus examination, though the definitive diagnosis is made by indocyanine green angiography (ICGA).2 Many studies have reported successful results with subfoveal PCV treatment by photodynamic therapy (PDT), anti-vascular endothelial growth factor (anti-VEGF) therapy, and combination therapy with both PDT and anti-VEGF.3 The gene discussed is VEGFA; the disease is age-related macular degeneration.