Some studies report comparisons of patients with active and inactive disease, or comparisons of patients’ data in active and inactive disease periods.10,11,13,14,26,27,28,31 Furthermore, increased leptin level has been observed with acute inflammatory stimuli like major surgery, though a leptin peak was not observed in chronic conditions such as rheumatoid arthritis and inflammatory bowel disease.48,49,50. The gene discussed is LEP; the disease is rheumatoid arthritis.