In the present analysis, we examined the relationship between baseline status and changes of lipid metabolism-associated parameters after long-term (260 weeks) GH therapy, in addition to effects on other metabolic parameters including glycated hemoglobin A1c (HbA1c), blood glucose and insulin levels before and after an oral glucose tolerance test (OGTT), homeostasis model assessment as an index of insulin resistance (HOMA-IR), and insulinogenic index. This evidence concerns the gene GH1 and Insulin resistance.