In addition, Rodway et al. have found that the inhibition of NB growth induced by 15-deoxy-PGJ2 can be reduced by the presence of serum lysolipids in the culture medium [14], while Emmans et al. reported that the degree of PPAR activation, due to 15-deoxy-PGJ2, in a NB cell line, is attenuated in the presence of the retinoblastoma protein (Rb) and restored by treatment with the histone deacetylase inhibitor trichostatin A (TSA). The gene discussed is PPARA; the disease is neuroblastoma.