MYCN and neuroblastoma: The most widely studied cytogenetic alterations, associated with poor outcome in NB, include N-myc oncogene amplification, loss or rearrangement of the distal portion of the short arm of chromosomes 1 (1p31-term), 3 (3p22), and 11 (11q23), gains of chromosome arm 1q or 17q, and the expression of the TrkB neurotrophin receptor and its ligand [34–38].