15-deoxy-Δ12,14-prostaglandin J2 (15-deoxy-PGJ2), a high-affinity natural ligand of PPAR-γ, inhibits in vitro growth and induces apoptosis in NB cells [11–16], through PPAR-γ-dependent ERK2 activation, although PPAR-γ-independent effects of 15-deoxy-PGJ2 have been also described [14]. The gene discussed is PPARG; the disease is neuroblastoma.