The new treatment protocols for NB currently under investigation consist of targeted radiotherapy and retinoid compounds (to induce terminal differentiation of NB cells), immunological treatment, such as using antidisialoganglioside 2 with or without association with cytokines (GM-CSF, IL-2), antiangiogenics, neurotrophin-signaling inhibitors, proapoptotic agents, allogeneic haemopoietic stem cell transplantation, and new chemotherapeutics [34, 39]. Here, CSF2 is linked to neuroblastoma.