YES1 and cancer: The findings that (1) the levels of pY232 and pY291 increase in several types of cancer, including breast, ovarian, and colon cancers and (2) pY232 and pY291 levels appear to correlate with CRC progression (27) are in line with observations that the elevated Src and Yes levels correlate with advanced stages and metastatic potential of tumors and poor prognosis (39–42).