SCN1A and Dravet syndrome: Interestingly, robust seizure protection was still achieved in Scn1a mutants when the current was doubled (48 mA for Scn1aRH/+ and 40 mA for Scn1a+/−), suggesting that Hup A might also provide protection against spontaneous seizures in DS that may initiate in the hippocampus (Liautard et al., 2013).