Thus, given the underlying reduction in neuronal inhibition (Yu et al., 2006; Ogiwara et al., 2007; Martin et al., 2010) and the known role of the hippocampus in seizure generation in DS (Liautard et al., 2013), the administration of Hup A would be predicted to enhance endogenous GABAergic tone, thereby normalizing the balance between neuronal inhibition and excitation in patients with SCN1A mutations. Here, SCN1A is linked to Dravet syndrome.