As Magel2 expression is absent in PWS-ICdel mice (Chamberlain et al. 2004, Relkovic et al. 2010), it is likely that correcting any imbalance in the oxytocin system in these animals may have similar beneficial effects, but whether this will prevent hyperphagia in adults and restore fat deposition remains to be determined. This evidence concerns the gene OXT and Prader-Willi syndrome.