GHRL and Prader-Willi syndrome: Given that the central circuits regulating both consummatory and appetitive feeding behaviours are activated by ghrelin (Nakazato et al. 2001, Lawrence et al. 2002, Keen-Rhinehart & Bartness 2005), the elevation in food intake and diet hoarding may result from the sustained hyperghrelinaemia seen in this model (Davies et al. 2015) and in humans with PWS (Cummings et al. 2002, DelParigi et al. 2002, Haqq et al. 2003, Erdie-Lalena et al. 2006, Bizzari et al. 2010).