CD4 and infection: As shown in Table 1, GS-9620 was inactive against HIV in isolated CD4+ T cells and macrophages up to the highest concentration tested (10 μM) but did show dose-dependent inhibition of HIV-1 replication in complete PBMCs following infection with either HIV-1BaL (EC50 = 536 nM) or HIV-1VSV-G-LUC (EC50 = 953 nM).