This is also, to our knowledge, the first time that expression of a single epigenetic transgene has led to lymphoma – expression of mutated polycomb-group gene EZH2 fails to drive lymphomagenesis unless in a background of overexpressed BCL2 or Myc (Béguelin et al., 2013; Berg et al., 2014). The gene discussed is EZH2; the disease is lymphoma.