Specifically, 100 % specificity and 82 % sensitivity for IBM was attained using a threshold value of 14.00 %, while 75 % specificity and 100 % sensitivity for IBM was achieved with a threshold value of 6.25 % fibers with the Keap1-positive protein aggregates; these sensitivity/specificity trade-offs are comparable to those seen with either LC3 or SQSTM1 immunohistochemistry for the same pair of disorders [15]. This evidence concerns the gene SQSTM1 and inclusion body myositis.