One region, containing SNPs associated with RA, SLE, CeD, IBD and T1D, tagged by the rs6920220 SNP, lies a considerable distance (>181 kb) from the TNFAIP3 gene and its functional role has, so far, been underexplored (Fig. 1g). This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.