Previous studies investigating the functional role of 6q23 disease variants had been restricted to the SNPs mapping to the LD block tagged by rs7752903 spanning the TNFAIP3 gene, associated with SLE, RA and celiac disease, showing that the TT > A variant, located downstream of TNFAIP3, impairs that gene’s expression through chromatin looping and altered NFκB binding [9, 30, 31, 40]. This evidence concerns the gene NFKB1 and celiac disease.