Indeed, our previous data showed that down-regulation of GMD factors UPF1, PNRC2, or GR promotes the chemotaxis of human acute monocytic leukemia cell lines (THP-1 cells) by up-regulating CCL2 mRNA and CCL2 protein (Cho et al. 2015). This evidence concerns the gene PNRC2 and acute monocytic leukemia.