High caspase-3 expression was significantly associated with the occurrence of death due to breast cancer (χ2=6.711; df=1; P = 0.01), recurrence (χ2=8.111; df=1; P = 0.004) and distant metastasis (χ2 = 5.724; df=1; P = 0.017) (Table 3). The gene discussed is CASP3; the disease is breast carcinoma.