Patients with high caspase-3/high calpain-1 expression, high caspase-3/high calpain-2 expression, high caspase-3/low calpastatin expression, or high caspase-8/low calpain-1 expression had significantly worse breast cancer-specific survival (P = 0.005, 0.049, 0.02, and 0.02 respectively) (Table 5). The gene discussed is CAST; the disease is breast cancer.