However, serum CA125 levels tended to be lower in CCC patients (median [interquartile range], 102.0 [45.5–309.5] U/mL) than in patients with non-CCC subtype EOCs (301 [109–1059] U/mL), as reported previously [14, 15] By contrast, serum TFPI2 levels were significantly (Mann–Whitney test; P < 0.0001) elevated in CCC patients (781.8 [381.4–1410] pg/mL) relative to patients with benign ovarian tumors (136.4 [99.93–191.0] pg/mL), borderline ovarian tumors (151.3 [137.7–192.1] pg/ml), or non-CCC subtype EOCs (208.5 [139.1–307.3] pg/ml). Here, MUC16 is linked to ovarian benign neoplasm.