In tumor specimens, intragenic PANCR methylation significantly correlated with PITX2ab (Spearman’s ρ = 0.390; p < 0.001; n = 80) but not PITX2c (Spearman’s ρ = 0.139; p = 0.23; n = 78), whereas PANCR methylation was significantly associated with PITX2c methylation in NAT (Spearman’s ρ = 0.328; p = 0.016; n = 53) but did not reach statistical significance for PITX2ab (Spearman’s ρ = 0.269; p = 0.054; n = 53). The gene discussed is BRD2; the disease is neoplasm.