Despite these limitations, our results and consideration of the work of others allow us to make the following conclusions: First, a third successive meal containing about 57 g of carbohydrates and contributing to a cumulative daily carbohydrate load of about 115 g, significantly reduces evening postprandial insulin and GIP responses and HOMA-IR estimate of insulin resistance, while the same number of iso-caloric meals containing about 120 g of carbohydrates and a daily carbohydrate load of 241 g contributes to evening postprandial hyperinsulinemia and a high HOMA-IR score. This evidence concerns the gene GIP and hyperinsulinism.