Circulating IL-8 level is higher in patients with idiopathic venous thrombosis[64]; IL-8 is involved in acute lung injury and acute respiratory distress syndrome through the generation of IL-8 and IL-8 autoantibody complexes and influence neutrophil apoptosis[65]; IL-8 level was significantly higher in patients in the acute myocardial infarction stages of coronary artery disease[66]. This evidence concerns the gene CXCL8 and medical procedure.