Amplifications that are involved in increased growth factor signaling among the GBM-associated LGA-shared CNAs include gains of segments containing the epidermal growth factor receptor EGFR (7p11.2), the hepatocyte growth factor receptor MET (7q31.2), and the fibroblast growth factor receptor (FGFR) substrate FRS2 (12q15) [45] (Fig C in S1 Appendix). This evidence concerns the gene FRS2 and glioblastoma.