Activated PPARγ increases the sensitivity of peripheral tissues to insulin, decreases insulin resistance and lowers blood glucose (Lazar 2005, Badman et al. 2007, King et al. 2007) through signaling pathways of acyl-CoA thioesterases and fibroblast growth factor 21 (FGF21) (Lazar 2005, Badman et al. 2007, King et al. 2007). Here, INS is linked to Insulin resistance.